The new era of APOL1-associated glomerulosclerosis
نویسندگان
چکیده
منابع مشابه
The new era of APOL1-associated glomerulosclerosis.
The association between apolipoprotein L1 gene (APOL1) variants and non-diabetic chronic kidney disease (CKD) has dramatically altered the landscape in nephrology [1, 2]. The pathogenesis of glomerulosclerosis is now better understood, providing the possibility of novel treatments and hope for millions with, and at risk of, CKD worldwide [3, 4]. The article by Tzur et al. [5] in the current iss...
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15 صفحه اولAPOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy.
Trypanolytic variants in APOL1, which encodes apolipoprotein L1, associate with kidney disease in African Americans, but whether APOL1-associated glomerular disease has a distinct clinical phenotype is unknown. Here we determined APOL1 genotypes for 271 African American cases, 168 European American cases, and 939 control subjects. In a recessive model, APOL1 variants conferred seventeenfold hig...
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15 صفحه اولRenal and Cardiovascular Morbidities Associated with APOL1 Status among African-American and Non-African-American Children with Focal Segmental Glomerulosclerosis
BACKGROUND AND OBJECTIVES African-American (AA) children with focal segmental glomerulosclerosis (FSGS) have later onset disease that progresses more rapidly than in non-AA children. It is unclear how APOL1 genotypes contribute to kidney disease risk, progression, and cardiovascular morbidity in children. DESIGN SETTING PARTICIPANTS AND MEASUREMENTS We examined the prevalence of APOL1 genotyp...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2012
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfr812